Challenges managing women with suspected Lynch Syndrome in Zimbabwe: a case report

Authors

  • Kotti-Emily Mukucha University of Zimbabwe
  • Marshall T Manase University of Zimbabwe
  • Charles Muronda Lancet Clinical Laboratories
  • Judith Whittaker Lancet Clinical Laboratories
  • Bothwell T Guzha University of Zimbabwe

Keywords:

Lynch syndrome, challenges in management, resource-poor countries, Zimbabwe

Abstract

Lynch Syndrome (LS) is associated with a genetic predisposition to colorectal, endometrial and multiple extracolonic cancers. The lifetime risk of developing endometrial and ovarian cancers is 40–62% and 4–12% respectively. The case is presented of a 56-year-old woman with a prior history of colorectal cancer who later developed endometrial carcinoma. Tumour immunohistochemistry showed microsatellite instability (MSI)-high, which is observed in 90% of LS-associated carcinomas. Germline molecular testing to confirm the diagnosis is not available in Zimbabwe. Her case is discussed together with the difficulties associated with the management of patients in Zimbabwe suspected to have LS.

Author Biographies

Kotti-Emily Mukucha, University of Zimbabwe

Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe

Marshall T Manase, University of Zimbabwe

Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe

Charles Muronda, Lancet Clinical Laboratories

Lancet Clinical Laboratories, Harare, Zimbabwe

Judith Whittaker, Lancet Clinical Laboratories

Lancet Clinical Laboratories, Cape Town, South Africa

Bothwell T Guzha, University of Zimbabwe

Department of Obstetrics and Gynaecology, University of Zimbabwe, Harare, Zimbabwe

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Published

2021-12-09

Issue

Section

Case Studies